Autoimmune, inflammatory and allergic diseases are highly heterogeneous conditions in their clinical phenotype. However, despite their heterogeneity, it has been shown that they share genetic risk, share some disease pathways, and share specific clinical manifestations.
Consequently, individuals with a disease may share an inflammatory molecular pattern with individuals with the other diseases. Hence, they may also share pathways of response to treatment and disease progression, which we will further investigate.
3TR will integrate the analysis of seven autoimmune, allergic, and inflammatory conditions to identify the relationship between longitudinal molecular and microbiome profiles in blood cells and tissues, and disease trajectories to characterise and better predict, why certain patient groups do not respond to certain treatments.